An ingredient commonly added to soap may cause cancer, scientists have warned






Soap chemical may cause liver fibrosis and cancer









Triclosan is an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items. Despite its widespread use, researchers at University of California, San Diego School of Medicine report potentially serious consequences of long-term exposure to the chemical. The study, published by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

“Triclosan’s increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit and present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action,” said Robert Tukey, who led the study, together with Bruce Hammock.


The team found that triclosan disrupted liver integrity and compromised liver function in mouse models. Mice exposed to triclosan for six months (roughly equivalent to 18 human years) were more susceptible to chemical-induced liver tumors. Their tumors were also larger and more frequent than in mice not exposed to triclosan.


The study suggests triclosan may do its damage by interfering with the constitutive androstane receptor, a protein responsible for detoxifying foreign chemicals in the body. To compensate for this stress, liver cells proliferate and turn fibrotic over time. Repeated triclosan exposure and continued liver fibrosis eventually promote tumor formation. Triclosan is perhaps the most ubiquitous consumer antibacterial. Studies have found traces in 97 per cent of breast milk samples and in the urine of nearly 75 per cent of people tested. Triclosan is also common in the environment.


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An ingredient commonly added to soap may cause cancer, scientists have warned
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